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If you’ve hit a weight loss plateau on Ozempic or Wegovy, PCOS or thyroid issues might be the reason. Learn what labs to order and how to fix it.
You started a GLP-1 medication like Ozempic, Wegovy, or Mounjaro (semaglutide or tirzepatide) to lose weight — and at first, it worked. But now you’re stuck. The scale isn’t moving, and you're wondering why.
Here’s the truth: it’s probably not your dose.
Hidden hormone issues like PCOS or thyroid imbalances could be getting in the way.
Both can disrupt your metabolism, hormones, and energy levels — making fat loss more difficult even with powerful medications like GLP-1s.
Figure 1. Strength Training Preserves Muscle and Accelerates Fat Loss in GLP-1 Users
Summary of cohort analysis reflecting trends across multiple observational studies:
GLP-1 users who engaged in structured strength training maintained significantly more lean body mass (LBM) while achieving greater fat mass reduction over 24 weeks. In contrast, users without strength training experienced compounded muscle loss, which may contribute to long-term metabolic slowdown and diminished composition outcomes.¹²³
References
¹ GLP-1 therapies and body composition – PubMed
² GLP-1 and exercise synergy – PMC
³ Mass General: Fitness for People Taking GLP-1 Agonists
Every pound of muscle burns more calories—even at rest. More muscle = more metabolic burn.
📈 Boost Metabolism
Every pound of muscle burns more calories—even at rest. More muscle = more metabolic burn.
Every pound of muscle burns more calories—even at rest. More muscle = more metabolic burn.
🧬 IGF-1 (Insulin-like Growth Factor-1)
GLP-1s are powerful, but they don’t build muscle — you have to.
Whether you're just starting, hitting a plateau, or tapering off, muscle is your metabolic insurance.
During weight loss → Muscle protects against fatigue and lean mass loss.
At the plateau → Muscle keeps the scale moving when meds slow down.
In maintenance → Muscle gives you more food flexibility and freedom.
When tapering off → Muscle protects you from rebound weight regain.
🧬 PeptideMD helps you track, preserve, and build the muscle that GLP-1s can’t.
Because long-term results aren’t just about weight — they’re about composition.
